Canine Distemper Vaccine Side Effects. If your dog has an allergic reaction to a vaccine or medication, it should be avoided and not used again on the dog. Side effects to feline distemper panleukopenia vaccination are rare and usually very minor.

Side effects of the da2pp vaccine are usually mild and localized, like a temporary bump at the injection site. Your dog may also get a rash. Local reactions include pain, swelling, abscesses, redness and irritation.