Can Skunk Spray Make You Sick. Thankfully, skunks don't go around looking to spray people and pets. A skunk that is healthy will always have a coat that is clean, well kept and glossy.

When the spray gets into a person’s mouth, throwing up. High concentrations of skunk spray are toxic and potentially fatal to humans, according to a 1999 study in chemical educator. Can breathing in skunk smell make you sick?